Free Scientific Resource on A Chimeric Approach to Purifying Lentiviral Vectors for CAR-T

Production of high-quality lentiviral vectors (LVV) for genetic modification of cells can be one of the most significant technical bottlenecks in product and process development for cell and gene therapies. How can upstream and downstream processing be optimized? What are the latest advancements that can take a process to the next level? These are critical questions that, if resolved early in the product development process, can have tremendous impact on cost and efficiency during scale-up and on-going GMP manufacturing. 

 This poster explains cutting-edge advancements in downstream processing for LVV manufacturing. You will learn about:   

  • Optimizing unit operations to achieve improved recovery and concentration of LVV
  • Closed-system processes for LVV manufacture
  • Novel, LVV-specific approaches for clarification, ultrafiltration/diafiltration and chromatography

If you are searching for information on developing the most effective gene and cell therapies using current state-of-the-art approaches in LVV manufacturing, this may be the resource for you. 

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