CDMO Blog

How Can a Closed CAR-T Manufacturing Process De-Risk Your Process, Reduce Costs and Improve Efficiency?

Instrument enabling Car-T process development

In a previous post we introduced chimeric antigen receptor T-cell (CAR-T) therapy - a new form of cancer therapy based on genetically reprogramming the body’s immune system that has been described as a “breakthrough” and “revolutionary” by the medical and scientific communities.

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Posted: Oct 24, 2019 3:22:49 PM

What is a Bioreactor and How is it Used in Cell and Gene Therapy?

ccrm-cdmo-Bioreactors-500px

Simply put, a bioreactor is a stand-alone cell culture vessel enabled with sensors. Bioreactors differ fundamentally from traditional R&D cell culture in their ability to monitor and control key parameters such as temperature, pH, and dissolved oxygen (DO). Continuous, in situ monitoring of these parameters allow for a deep understanding of the growth environment of a given cell population -- creating avenues for process improvement. Paired controls enable dynamic, real-time responses as cells grow and the culture changes over time. With these capabilities, bioreactors can overcome limitations of traditional cell culture enabling the use of cell culture for commercial or clinical purposes.

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Posted: Oct 24, 2019 2:08:46 PM

How Can a Contract Development and Manufacturing Organization (CDMO) Advance a Cell & Gene Therapy Product?

Contract Development and Manufacturing Organization for cell and gene therapies

Making the Decision to Engage a CDMO

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Posted: Oct 22, 2019 3:44:48 PM